| 1 | Valentín Castellanos
New York City FC | New York City FC | 35 | 21 |
| 2 | Ola Kamara
D.C. United | D.C. United | 28 | 19 |
| - | Hany Mukhtar
Nashville SC | Nashville SC | 33 | 19 |
| 4 | Javier Hernández
LA Galaxy | LA Galaxy | 21 | 17 |
| - | Adam Buksa
New England Revolution | New England Revolution | 32 | 17 |
| - | Raúl Ruidíaz
Seattle Sounders | Seattle Sounders | 27 | 17 |
| 7 | Johnny Russell
Sporting Kansas City | Sporting Kansas City | 32 | 16 |
| - | Dániel Sallói
Sporting Kansas City | Sporting Kansas City | 32 | 16 |
| - | Damir Kreilach
Real Salt Lake | Real Salt Lake | 36 | 16 |
| 10 | Gustavo Bou
New England Revolution | New England Revolution | 31 | 15 |
| 11 | Cristian Daniel Arango Duque
Los Angeles FC | Los Angeles FC | 17 | 14 |
| 12 | Ricardo Pepi
FC Dallas | FC Dallas | 31 | 13 |
| - | Felipe Mora
Portland Timbers | Portland Timbers | 33 | 13 |
| 14 | Josef Martínez
Atlanta United FC | Atlanta United FC | 25 | 12 |
| - | Brian White
Vancouver Whitecaps | Vancouver Whitecaps | 28 | 12 |
| - | C.J Sapong
Nashville SC | Nashville SC | 35 | 12 |
| - | Gonzalo Higuaín
Inter Miami CF | Inter Miami CF | 30 | 12 |
| - | Lucas Zelarrayan
Columbus Crew SC | Columbus Crew SC | 32 | 12 |
| - | Kacper Przybylko
Philadelphia Union | Philadelphia Union | 37 | 12 |
| 20 | Daryl Dike
Orlando City SC | Orlando City SC | 19 | 11 |
| - | Javier Eduardo López Ramírezírez
San Jose Earthquakes | San Jose Earthquakes | 32 | 11 |
| - | Fabrice-Jean Picault
Houston Dynamo | Houston Dynamo | 31 | 11 |
| - | Cristian Andres Dajome Arboleda
Vancouver Whitecaps | Vancouver Whitecaps | 34 | 11 |
| - | Albert Rusnák
Real Salt Lake | Real Salt Lake | 35 | 11 |
| 25 | Nani
Orlando City SC | Orlando City SC | 29 | 10 |
| - | Dairon Estibens Asprilla Rivas
Portland Timbers | Portland Timbers | 37 | 10 |
| 27 | Anderson Julio
Real Salt Lake | Real Salt Lake | 33 | 9 |
| - | Sebastián Blanco
Portland Timbers | Portland Timbers | 27 | 9 |
| - | Gyasi Zerdes
Columbus Crew SC | Columbus Crew SC | 21 | 9 |
| - | Tajon Buchanan
New England Revolution | New England Revolution | 28 | 9 |
| - | Robin Lod
Minnesota United FC | Minnesota United FC | 24 | 9 |
| - | Jáder Rafael Obrian Arias
FC Dallas | FC Dallas | 34 | 9 |
| - | Jesús Manuel Medina Maldonado
New York City FC | New York City FC | 37 | 9 |
| - | Marcelino Moreno
Atlanta United FC | Atlanta United FC | 33 | 9 |
| 35 | Miguel Berry
Columbus Crew SC | Columbus Crew SC | 18 | 8 |
| - | Rommel Quioto
CF Montréal | CF Montréal | 19 | 8 |
| - | Luka Stojanovic
Chicago Fire | Chicago Fire | 27 | 8 |
| - | Alan Pulido
Sporting Kansas City | Sporting Kansas City | 22 | 8 |
| - | Michael David Barrios Puerta
Colorado Rapids | Colorado Rapids | 34 | 8 |
| - | Patryk Klimala
New York Red Bulls | New York Red Bulls | 30 | 8 |
| - | Robert Beric
Chicago Fire | Chicago Fire | 33 | 8 |
| - | Jesús Ferreira
FC Dallas | FC Dallas | 27 | 8 |
| - | Randall Leal
Nashville SC | Nashville SC | 33 | 8 |
| - | Rubio Rubin
Real Salt Lake | Real Salt Lake | 37 | 8 |
| - | Brenner Souza da Silva
FC Cincinnati | FC Cincinnati | 33 | 8 |
| 46 | Mason Toye
CF Montréal | CF Montréal | 14 | 7 |
| - | Franco Jara
FC Dallas | FC Dallas | 29 | 7 |
| - | Ismael Tajouri
New York City FC | New York City FC | 26 | 7 |
| - | Jonathan Lewis
Colorado Rapids | Colorado Rapids | 28 | 7 |
| - | Fredy Montero
Seattle Sounders | Seattle Sounders | 30 | 7 |